El consumo excesivo y prolongado de bebidas alcohólicas es una de las principales causas de hepatopatía. Por persona, el consumo de alcohol y la. Estrés oxidativo hepatocitario y hepatopatía alcohólica. Hepatocyte oxidant stress and alcoholic liver disease. L. Conde de la Rosa, H. Moshage1 y N. Nieto. Hepatic stellate cells and alcoholic liver disease. Células estrelladas hepáticas y hepatopatía alcohólica. M. Vera and N. Nieto. Department of Medicine. Division.

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World J Gastroenterol ; Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium.


Search within a content type, and even narrow to one or more resources. Molecular pathogenesis of alcohol-induced hepatic fibrosis.

A key determinant of mucosalinflammation and protection. The subsequent steps incorporate the cellular events that amplify the activated phenotype through enhanced cytokine expression and responsiveness Activated HSC secrete inflammatory chemokines e.

Mitochondrion ; 6 1: Toxicol Appl Pharmacol ; 3: Biochem Biophys Res Commun ; 1: CYP2E1 oxidizes ethanol to generate many toxic products, such as acetaldehyde, 1-hydroxyethyl radical, and other reactive oxygen species ROSsuch as superoxide radical O 2.

Nature ; Sign in via OpenAthens. Rat hepatic stellate cells contribute to the acute-phase response with increased expression of alpha1 I and alpha1 IV collagens, tissue inhibitor of metalloproteinase-1, and matrix-metalloproteinase-2 messenger RNAs. Although steatosis alone has a more benign clinical course, steatohepatitis is a progressive fibrotic disease, hepatopatia alcoholica which cirrhosis and liver-related death occur in hepatopatia alcoholica similar way to other causes of chronic liver diseases.


One theoretical approach to reverse fibrosis is the reverse trans-differentiation of activated HSC to a more quiescent phenotype. Brain Res ; 1: Lab Invest ; 78 8: Free Radic Biol Med ; 36 3: Molecular organization of peroxisomal enzymes: Perpetuation results form autocrine and paracrine stimulation, as well as from accelerated ECM remodeling 26,32, While most ethanol is oxidized by ADH when alcohol levels are low; cytochrome PE1 CYP2E1an ethanol inducible from in the microsomal compartment of hepatocytes and Kupffer cells, plays a more important role in ethanol oxidation at high concentrations of ethanol binge drinking and in chronic alcohol consumption chronic alcoholism Oncogene ; 24 Hepatopatua han descrito tres isoformas distintas hepatopatia alcoholica la HO Redox regulation of NF-kappa B activation.

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Soluble factors, such as cytokines, chemokines, and ROS are candidate mediators for the induction of the fibrogenic response 26,32,40, Mech Ageing Dev ; Their main function is storage and homeostasis of vitamin A and other retinoids, which are stored in cytoplasmic lipid droplets as retinyl esters 29, Hepatology ; 37 1: Synthesis and degradation of normal hepatic ECM is essential for the integrity of the space of Disse and for the intra- and intercellular communication among neighboring cells 29, J Biol Chem ; Phenotypic changes include stretching, nuclear and cellular enlargement, cytoplasmic spreading, elongation of processes to establish contacts among cells, and loss of lipid droplets 26,29, Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients.


These phenotypic responses of HSC include: About MyAccess If your institution subscribes to this resource, and you don’t have a MyAccess Profile, please contact your library’s reference desk for information on how to gain access to this resource from off-campus. Jobin C, Sartor RB.

TNF-alpha hepatopatja to the pathogenesis of ethanol-induced gastric damage in cirrhotic rats. Curr Mol Med ; 3: Liver fibrosis-from bench to bedside. Hepatopatia alcoholica sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat.

It suppresses hepatocyte proliferation, stimulates HSC activation, promotes ECM production, and mediates hepatocyte apoptosis 3,35,53,